Zona A
| 12/03/21 | |
| NUEVA CHICAGO 1 Matos | MITRE DE SANTIAGO 2 Cérica Torres |
| 13/03/21 | |
| ALMIRANTE BROWN 2 Guzmán Vera | ESTUDIANTES BS AS 1 Bolzicco |
| 13/03/21 | |
| BELGRANO CBA 2 Ruiz Gómez Vegetti | TIGRE 1 Magnín |
| 13/03/21 | |
| GIMNASIA MZA 2 Lentini 2 | AGROPECUARIO 0 |
| 14/03/21 | |
| ESTUDIANTES DE RIO IV 1 Beraldi | MAIPU MZA 1 Veliez |
| 14/03/21 | |
| SAN MARTIN DE TUCUMAN 0 | ALVARADO 0 |
| 15/03/21 | |
| RIESTRA 0 | QUILMES 1 Acevedo |
| 13/03/21 | |
| CHACARITA 0 | ATLANTA 1 Colombini |
Libre: TEMPERLEY
Zona B
| 12/03/21 | |
| SAN MARTIN DE SAN JUAN 4 Ruiz Villagra Campana 2 | ATLETICO DE RAFAELA 2 Portillo Bieler |
| 13/03/21 | |
| ALL BOYS 1 Compacnucci | MORON 3 Guaycochea Broggi Pacheco |
| 13/03/21 | |
| DEFENSORES DE BELGRANO 0 | INSTITUTO CBA 0 |
| 13/03/21 | |
| SANTAMARINA 2 Michel Depietri | GIMNASIA DE JUJUY 1 D.López |
| 13/03/21 | |
| SAN TELMO 1 Zurita | BARRACAS CENTRAL 1 Estigarribia |
| 13/03/21 | |
| VILLA DALMINE 0 | INNDEPENDIENTE RIVADAVIA MZA 0 |
| 14/03/21 | |
| ATLETICO GÜEMES 2 Vega Bayk | FERRO 0 |
| 14/03/21 | |
| BROWN 1 Bruera | GUILLERMO BROWN 0 |
| 15/03/21 | |
| ALMAGRO 1 Servetto | TRISTAN SUAREZ 3 Molina 2 Melillo |
